Dallas Buyers Club
Dallas Buyers Club
ABOUT DALLAS BUYERS CLUB
Ronald Dickson Woodroof (February 3, 1950 – September 12, 1992) was an American man who created what would become known as the Dallas Buyer's Club in March 1988, one of several such AIDS buyers clubs that sprang up at the time. After contracting HIV in 1985, he created the group as part of his efforts to find and distribute drugs to treat HIV at a time when the disease was poorly understood. He sued the United States Food and Drug Administration (FDA) over a ban on peptide T, a drug he was using. Woodroof's final years became the basis of the 2013 film Dallas Buyers Club. Seven years following his diagnosis of HIV, Ron Woodroof died on September 12, 1992, from pneumonia brought on by AIDS.
In the 2013 biographical film Dallas Buyers Club, protagonist Ron Woodroof promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer's disease and sues the FDA over their efforts to limit his ability to use peptide T, as it was an unapproved medicine.
Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert and Michael Ruff, a US neuroscientist and immunologist. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related to HIV disease and Neuro-AIDS. Peptide T clinical development was stopped due to the propensity of the liquid nasal spray to lose potency upon storage and shifted to its shorter oral analog, the pentapeptide CCR2/CCR5 antagonist RAP-103 (Receptor Active Peptide) for neuropathic pain and neurodegeneration. RAP-103 also blocks CCR8, which may be important in neuropathic pain. Inhibitors of CCR5, including DAPTA, prevent and reverse neurodegeneration and are therapeutic targets in stroke/brain injury and dementia, such as in Parkinsons Disease dementia.